Unicode representation of my current WeeChat (IRC) screen layout.

┌---┬---------------------┬------------┐
|   |  Server Monitoring  | Highlights |
|   |                     |            |
|   ├----------------┬----┴------------┤
| B |                |  Clone Scanner  |
| U | Channel Monitor├-----------------┤
| F |                |  Twitter Feed   |
| F ├---------------┬┴┬----------------┤
| E |               |N|                |
| R |    Active     |I|     Active     |
| S |    Channel    |C|     Query      |
|   |   Window 1    |K|    Window 1    |
| L |               |S|                |
| I ├---------------┴-┼----------------┤
| S |                 |                |
| T |    Active       |     Active     |
|   |    Channel      | Channel/Query  |
|   |   Window 2      |    Window 2    |
|   |                 |                |
└---┴-----------------┴----------------┘

• 'Nicks' indicates the optional nicklists for given channels. They can be toggled and are hidden by default (as is shown in 'Active Channel Window 2').
• 'Buffers List' shows a clickable list of all channels, private conversations, server screens and other 'buffers' I have open.
• 'Server Monitoring' shows information such as reported open proxies, triggered spam-filters and server bans.
• 'Channel Monitor' shows conversations from all the channels I have open. Monitoring of individual channels can be toggled; so for instance high-traffic channels can be hidden from the monitor.
• 'Highlights' shows all triggered highlights. The window is kept small, since there usually isn't a lot of activity in it; it's more there so I can notice any new highlights. For a detailed view I can hit alt+h to 'zoom' in on that window.
• Switching windows is done by pressing ctrl+cursor keys.
• Switching buffers is done by clicking on the desired buffer in the 'Buffers List', or by pressing alt+j followed by the buffer number, or just alt+0-9 if the buffer number is <11.
• /Whois replies are shown in the target-user's private buffer, or in the current buffer if no private buffer for that user is open.
• 'Active Channel Window' 1 and 2 I use for displaying the 2 channels I'm most active in at the moment
• 'Active Query Window 1' is a window I have reserve for query conversations.
• 'Active Channel/Query Window 2' is usually reserved for query conversations, but is occasionally used as a third Channel window as well.
• 'Clone Scanner' displays notifications if someone joins a channel from a host that already has 1 or more connections. Will probably drop this window as I rarely check it and already have in-buffer notifications as well.
• 'Twitter Feed' displays incoming Twitter messages. I tend to forget to log into my Bitlbee server though, so it often is empty...

Commands to get this window layout

/window splith 12
/window 2
/window splitv 68
/window 1
/window splith 20
/window 4
/window splitv 60
/window 1
/window splith 50
/window splitv 65
/window 1
/window splitv 65